Discovery engagement
Biomarker discovery sprint
A bounded evidence and data review that turns a broad biomarker question into a prioritised set of testable candidates, assumptions and next-step experiments.
01
Scientific problem
Research teams can face long candidate lists produced by statistical association, literature review or preliminary experiments; the immediate need is a transparent way to combine evidence, expose uncertainty and decide what is worth validating.
02
Appropriate users
Translational research teams with a defined disease or phenotype, intended specimen context, target modality and access to relevant internal or public evidence.
03
What ASR does
Refine the question, intended use and candidate criteria; review available study design, data and public evidence; agreed exploratory analysis or evidence synthesis; transparent prioritisation criteria; candidate rationale with supporting evidence, conflicts and gaps; validation questions and next experiments. Exclusions: No claim of clinical validity, diagnostic performance, causal mechanism or successful wet-lab validation. The sprint prioritises hypotheses; it does not certify a biomarker.
04
Typical inputs
Research question; disease/phenotype and specimen context; existing candidate list where available; processed molecular data or identified public datasets; inclusion/exclusion criteria; intended next decision.
05
Outputs
Scoping and evidence map; documented prioritisation framework; ranked or grouped candidate table with evidence trace and uncertainty; selected supporting visualisations; technical brief and validation recommendations; review meeting.
06
Typical timeline
Set after evidence/data readiness review
07
Engagement model
Fixed-scope discovery/scoping engagement